TOTANI LABORATORY
Publications　　　　　　　　　　　　　　　　　　 研究業績

Scientific Papers / 学術論文

94.  Taiki Kuribara, Taiga Kojima, Yuka Kobayashi, Mitsuaki Hirose, Youichi Takeda, Kiichiro Totani, Development of calreticulin-targeting ligand based on a hybrid binding concept, Glycobiology, 35, cwaf015 (2025).  Editor’s Choice に選出


93.  廣瀬光了，戸谷希一郎，高マンノース型糖鎖関連化合物G1M9-Asn(Fmoc)-Gly-Thr の鶏卵からの調製法，成蹊大学理工学研究

       報告，61, 17-20 (2024).


92.  Taiki Kuribara, Mitsuaki Hirose, Naoya Tajima, Kiichiro Totani, Chemical study of high-mannose-type glycan-related proteins to

       understand their functions at the molecular level, Trends on Glycoscience and Glycotechnology, 36, E92-E103 (2024).


91.  Mitsuaki Hirose, Yuto Nakamachi, Hasumi Muto, Akito Taira, Shinji Tanaka, Taiki Kuribara, Kiichiro Totani, Preparation of natural

       high-mannose-type oligosaccharides (Glc1Man9GlcNAc2) with the asparagine-glycine-threonine as consensus sequence from chiken egg

       yolk, Carbohydrate Research, 540, 109138 (2024).

 

90.  Ruchio Usui, Akira Koizumi, Kyohei Nitta, Taiki Kuribara, Kiichiro Totani, Multisite partial glycosylation approach for preparation of biologically relevant oligomannosyl branches contribute to lectin affinity analysis, The Jornal of Organic Chemistry, 88, 14357-14367 (2023). Supplementary Cover に採択


  1. 89. Shigesaburo Ogawa, Katsuya Iuchi, Taro Tsubomura, Kiichiro Totani, Setsuko Hara, Stabilizer-free vitamin E nanovehicle for biological research, Journal of Oleo Science, 71, 1531-1540 (2022).


88.  Taiki Kuribara, Kiichiro Totani, Oligomannose-type glycan processing in the endoplasmic reticulum and its importance in misfolding diseases, Biology 11, 199, (2022).


87.   Yuichi Kawanobe, Naoya Kuragaki, Taro Tsubomura, Yasuomi Yamazaki, Taiki Kuribara, Kiichiro Totani, Mechanistic Study of silyl-assisted effect on 1,2-cis-α-glucosylation, ChemistrySelect 7, e202104152, (2022).


86.  栗原大輝，戸谷希一郎，合成３糖類が明かす小胞体マンノシダーゼ群のエンド結合識別能，成蹊大学理工学研究報告，58, 29-34 (2021).


85.   Chikahiro Imashiro, Tetsuya Azuma, Shun Itai, Taiki Kuribara, Kiichiro Totani, Hiroaki Onoe, Kenjiro Takemura, Travelling ultrasound promotes vasculogenesis of three-dimensional-monocultured human umbilical vein endothelial cells, Biotechnology and Bioengineering, 118, 3760-3769 (2021).


84.   Kyohei Nitta, Taiki Kuribara, Kiichiro Totani, Synthetic trisaccharides reveal discrimination of endo-glycosidic linkages by exo-acting α-1,2-mannosidases in the endoplasmic reticulum, Organic & Biomolecular Chemistry, 19, 4137-4145 (2021).


83.   Taiki Kuribara, Ruchio Usui, Kiichiro Totani, Glycan structure-based perspectives on the entry and release of glycoproteins in the calnexin/calreticulin cycle, Carbohydrate Research, 502, 108273 (2021).


82.   Taiki Kuribara, Kiichiro Totani, Structural insights into N-linked glycan-mediated protein folding from chemical and biological perspectives, Current Opinion in Structural Biology, 68, 41-47 (2021).


81.   Kiichiro Totani, Kaoru Arima, Taiki Kuribara, Yui Satake, Makoto Hirano, Perturbation of the relative contribution of molecular chaperones in the endoplasmic reticulum, ACS Omega, 5, 7399-7405 (2020).


80.   Taiki Kuribara, Ayami Imagawa, Makoto Hirano, Yukishige Ito, Kiichiro Totani, Metabolic syndrome perturbs de-glucosylation and

　　re-glucosylation in glycoprotein folding cycle, FEBS Letters, 594. 1759-1769 (2020).


79.   Wresti L. Anggayasti, Chikahiro Imashiro, Taiki Kuribara, Kiichiro Totani, Kenjiro Takemura, Low-frequency mechanical vibration induces apoptosisof A431 epidermoid carcinoma cells, Engineering in Life Sciences, 20, 232-238 (2020).


78.  栗原大輝，戸谷希一郎，小胞体糖タンパク質品質管理における多機能生タンパク質，成蹊大学理工学研究報告，56, 21-24 (2019).


77.   Yuta Kurashina, C hikahiro Imashiro, Makoto Hirano, Taiki Kuribara, Kiichiro Totani, Kiyoshi Ohnuma, James Friend, Kenjiro Takemura, Enzyme-free release of adhered cells from standard culture dishes using intermittent ultrasonic traveling waves, Communications Biology, 2, 393 (2019).


76.   Kiichiro Totani, Glycoprotein quality control contributed by secondary factors, Trends in Glycoscience and Glycotechnology, 31, SE59-SE60 (2019).


75.   Hanako Tauchi, Chikahiro Imashiro, Taiki Kuribara, Genichiro Fujii, Yuta Kurashina, Nozomi, Kiichiro Totani, Kenjiro Takemura, Effective and intact cell detachment from a clinically ubiquitous culture flask by combining ultrasonic wave exposure and diluted trypsin, Biotechnology and Bioprocess Engineering, 24, 536-543 (2019).


74.   Kanae Sano, Taiki Kuribara, Nozomi Ishii, Ayumi Kurokawa, Toshitada Yoshihara, Seiji Tobita, Kiichiro Totani, Ichiro Matsuo, Fluorescence quenching-based assay for measuring Golgi endo-α-mannosidase, Chemistry-An Asian Journal, 14, 1965-1969 (2019).


73.   Misa Nakao, Chikahiro Imashiro, Taiki Kuribara, Yuta Kurashina, Kiichiro Totani, Kenjiro Takemura, Formation of large scaffoled-free three-dimensional aggregates in a cell culture dish by ultrasound standing wave trapping, Ultrasound in Medicine and Biology, 45 (5), 1306-1315 (2019).


72.   Chikahiro Imashiro, Yuta Kurashina, Taiki Kuribara, Makoto Hirano, Kiichiro Totani, Kenjiro Takemura, Cell patterning method on a clinically ubiquitous culture dish using acoustic pressure generated from resonance vibration of a disk-shaped ultrasonic transducer, IEEE Transaction on Biomedical Engineering, 66(1), 111-118 (2019).


71.   Shigesaburo Ogawa, Koji Honda, Taro Tsubomura, Kiichiro Totani, Isao Takahashi, Setsuko Hara, Physicochemical characterization of

        6-O-acyl trehalose fatty acid monoesters in desiccated system, Chemistry and Physics of Lipids, 216, 80-90 (2018).


70.   Taiki Kuribara, Kiichiro Totani, Bifunctionality of glycan-recognizing proteins in N-glycoprotein biosynthesis, Medical Research Archives, 6, 1852 (2018).


69.   栗原大輝，戸谷希一郎, 小胞体内における1-デオキシノジリマイシン結合マンノシダーゼの選別, 成蹊大学理工学研究報告, 54,

        25-27 (2017).


68.   Taiki Kuribara, Toshihiro Ishihara, Takaya Kudo, Makoto Hirano Kiichiro Totani, Peptide specificity analysis of peptide:N-glycanases using synthetic chitobiose-pentapeptides, Protein & Peptide Letters, 24, 723-728 (2017).


67.   Yuta Kurashina, Makoto Hirano, Chikahiro Imashiro, Kiichiro Totani, Jun Komotori, Kenjiro Takemura, Enzyme-free cell detachment mediated by resonance vibration with temperature modulation, Biotechnology and Bioengineering, 114, 2279-2288 (2017).

　　重要論文としてFront Cover に採択。


  1. 66.  Shogo Iwamoto, Yuta Kasahara, Yayoi Yoshimura, Akira Seko, Yoichi Takeda, Yukishige Ito, Kiichiro Totani, Ichiro Matsuo, Endo-a-mannosidase catalyzed transglycosylation, ChemBioChem, 18, 1376-1378 (2017).

       重要論文としてInside Cover に採択。


65.Taiki Kuribara, Makoto Hirano, Gaetano Speciale, Spencer J. WIlliams, Yukishige Ito, Kiichiro Totani, Selective manipulation of discrete mannosidase activities in the endoplasmic reticulum by using reciprocally selective inhibitors, ChemBioChem, 18, 1027-1035 (2017).

　　Very Important Paper (VIP) に採択。

　　重要論文としてInside Coverに採択。


64.Kiichiro Totani, Kenta Yamaya, Makoto Hirano, Yukishige Ito, Influence of aglycone structures on N-glycan processing reactions in the endoplasmic reticulum, Carbohydrate Research, 439, 16-22 (2017).


63.Makoto Hirano, Kiichiro Totani, Tomohiko Fukuda, Jianguo Gu, Akemi Fukuda, N-Glycoform-dependent interactions of megalin with its ligands, BBA-General Subjects, 1861, 3106-3118 (2017).


62.   Makoto Hirano, Ayami Imagawa, Kiichiro Totani, Stratified analysis of lectin-like chaperones in the folding disease-related metabolic syndrome rat model, Biochemical and Biophysical Research Communications, 478, 247-253 (2016).


61.   Makoto Hirano, Yuka Adachi, Yukishige Ito, Kiichiro Totani, Calreticulin discriminates the proximal region at the N-glycosylation site of Glc1Man9GlcNAc2 ligand , Biochemical and Biophysical Research Communications, 466, 350-355 (2015).


60.   Kiichiro Totani, Yuki Shinoda, Masaaki Shiba, Shogo Iwamoto, Akira Koizumi, Yuji Matsuzaki, Makoto Hirano, Silyl-assisted 1,2-cis-α-glucosylation for the synthesis of a triglucoside moiety in high-mannose-type oligosaccharides, RSC Advances, 5, 75918-75922 (2015).


59.   Makoto Hirano, Yuki Kato, Ayami Imagawa, Kiichiro Totani, Analytical method for determining relative chaperone activity using an ovalbumin-conjugated column, Biochemical and Biophysical Research Communications, 456, 333-338 (2015).


  1. 58.  平野真，戸谷希一郎, サーマルシフトアッセイによるカルレティキュリン-糖鎖相互作用解析, 成蹊大学理工学研究報告, 52,

      19-24 (2015).


57.   Takaya Kudo, Makoto Hirano, Toshihiro Ishihara, Shun Shimura, Kiichiro Totani, Glycopeptide probes for understanding peptide specificity of the folding sensor enzyme UGGT, Bioorganic & Medicinal Chemistry Letters, 24, 5563-5567 (2014).


56.   Hikaru Matsushima, Makoto Hirano, Yukishige Ito, Kiichiro Totani, Diverse Effects of Macromolecular Crowding on the Sequential Glycan Processing Pathway Involved in Glycoprotein Quality Control, ChemBioChem, 14, 753-758 (2013).


55.   Shogo Iwamoto, Miho Isoyama, Makoto Hirano, Kenta Yamaya, Yukishige Ito, Ichiro Matsuo, Kiichiro Totani, Reconstructed Glycan Profile for Evaluation of Operating Status of the Endoplasmic Reticulum Glycoportein Quality Control, Glycobiology, 23, 121-131 (2013).


54.   栗原大輝，平野真，戸谷希一郎, 小胞体糖鎖プロセシングに対する選択的阻害, 成蹊大学理工学研究報告, 50, 109-112 (2013).


53.   Kiichiro Totani, Recent Chemical Approaches to Mimicking High-Mannose Glycans, Trends in Glycoscience and Glycotechnology, 24(138), 190-192 (2012).


52.   Mayumi Nakamura, Yuka Adachi, Kiichiro Totani, Property of Jack Bean α-Mannosidase in the Presence of Hyaluronan, Bioscience, Biotechnology, and Biochemistry, 76, 856-858 (2012).


51.   Takashi Ishikawa, Hiroto Noritake, Kiichiro Totani, Influence of Hyaluronan Environments on the Stereoselectivity of an Aldol Reaction, Journal of the Chinese Chemical Society,  59, 265-268 (2012).


50.   Kiichiro Totani, Haruka Miyazawa, Shino Kurata, Yukishige Ito, 「Mild enrichment procedure」〜Dynabeadsを用いた弱活性レクチンの単離〜，VERITAS Science Letter, vol.8, (2012).


49.   戸谷希一郎, 高尾賢一, 只野金一, 糖質由来のキラルテンプレートを用いた立体選択的炭素-炭素結合形成反応の開発, 有機合成化学協会誌, 69, 1363-1374 (2011).


48.   Kiichiro Totani, In vivo Glycorandomization for Facile Access to Diverse Glycosides, Trends in Glycoscience and Glycotechnology, 23, 153-154 (2011).


47.   Kiichiro Totani, Haruka Miyazawa, Shino Kurata, Yukishige Ito, Magnetic Beads-Assisted Mild Enrichment Procedure for Weak-Binding Lectins, Analytical Biochemistry, 411, 50-7 (2011).


  1. 46.  中村真由美，足立優花, 戸谷希一郎，ヒアルロナンが形成する網目環境場が酵素反応に与える影響, 成蹊大学理工学研究報告,

      48, 101-104 (2011).


45.   Kiichiro Totani, Chemistry of Glycoprotein Quality Control, Trends in Glycoscience and Glycotechnology, 22 (128), 296-307 (2010).


44.   Atsushi Miyagawa, Kiichiro Totani, Ichiro Mastuo, Yukishige Ito, Promiscuous Activity of ER Glucosidase II Discovered Through Donor Specificity Analysis of UGGT, Biochemical and Biophysical Research Communications, 403 (3-4), 322-328 (2010).


43.   Yoichi Takeda, Kiichiro Totani, Ichiro Matsuo, Yukishige Ito, The action of bromoconduritol on ER glucosidase II, Bioorganic Medicinal Chemistry Letters, 20, 5357-5359 (2010).


42.   戸谷希一郎, 代謝機能解析システム, 成蹊大学理工学研究報告, 47, 33-34 (2010).


41.   Kiichiro Totani, How is endoplasmic reticulum stress related to oligosaccharide function?, Trends in Glycoscience and Glycotechnology, 21 (121), 305-307 (2009). 


40.   Hu Dan, Yukiko Kamiya, Kiichiro Totani, Daiki Kamiya, Norihito Kawasaki, Daisuke Yamaguchi, Ichiro Matsuo, Naoki Matsumoto, Yukishige Ito, Koichi Kato, Kazuo Yamamoto, Sugar-binding activity of the MRH domain in the ER α-glucosidase II β subunit is important for efficient glucose trimming, Glycobiology, 19 (10), 1127-1135 (2009).


39.   Yoichi Takeda, Kiichiro Totani, Ichiro Matsuo, Yukishige Ito, Chemical approaches toward understanding glycan-mediated protein quality control, Current Opinion in Chemical Biology, 13 (5-6), 582-591 (2009).


38.   Yoshimi Haga, Kiichiro Totani, Yukishige Ito, Tadashi Suzuki, Establishment of a real-time analytical method for free oligosaccharide transport from the ER to the cytosol, Glycobiology, 19 (9), 987-994 (2009).


37.   Taisuke Watanabe, Kiichiro Totani, Ichiro Matsuo, Jun-ichi Maruyama, Katsuhiko Kitamoto, Yukishige Ito, Genetic analysis of glucosidase II β-Subunit in trimming of high-mannose-type glycans, Glycobiology, 19 (8), 834-840 (2009).


36.   Kiichiro Totani, Yoshito Ihara, Takashi Tsujimoto, Ichiro Matsuo, Yukishige Ito, The Recognition motif of the glycoprotein-folding sensor enzyme, UDP-Glc: glycoprotein glucosyltransferase, Biochemistry, 48 (13), 2933-2940 (2009).


35.   戸谷希一郎，藏田紫乃, 糖鎖磁気ビーズを用いた糖鎖認識タンパク質の同定, 成蹊大学理工学研究報告, 46, 91-97 (2009).


34.   Tadashi Suzuki, Ichiro Matsuo, Kiichiro Totani, Sho Funayama, Junichi Seino, Naoyuki Taniguchi, Yukishige Ito, Sumihiro Hase, Dual-gradient HPLC for identification of cytosolic high mannose-type free glycan, Analytical Biochemistry, 381, 224-232 (2008).


33.   Sachiko Nakamura-Tsuruta, Noboru Uchiyama, Willy J. Peumans, Els J.M. Van Damme, Kiichiro Totani, Yukishige Ito, Jun Hirabayashi, Analysis of the sugar-binding specificity of mannose-binding Jacalin-related lectins by frontal affinity chromatography - an approach to functional classification, FEBS Journal 275 (6), 1227-1239 (2008).


32.   Kiichiro Totani, Yoshito Ihara, Ichiro Matsuo, Yukishige Ito, Effects of macromolecular crowding on glycoprotein processing enzymes, Journal of the American Chemical Society, 130 (6), 2101-2107 (2008).


31.   Norihito Kawasaki, Yoko Ichikawa, Ichiro Matsuo, Kiichiro Totani, Naoki Matsumoto, Yukishige Ito, Kazuo Yamamoto, The Sugar-Binding Ability of ERGIC-53 is Enhanced by its Interaction with MCFD2, BLOOD, 111, 1972-1979 (2008).


30.   戸谷希一郎, 糖タンパク質品質管理機構解明に向けた合成化学的アプローチ, 成蹊大学理工学研究報告, 45, 15-25 (2008).


29.   Daisuke Yamaguchi, Norihito Kawasaki, Ichiro Matsuo, Kiichiro Totani, Hideto Tozawa, Naoki Matsumoto, Yukishige Ito, Kazuo Yamamoto, VIPL has sugar-binding activity specific for high mannose-type N-glycans, and glucosylation of the α1,2 mannotriosyl branch blocks its binding, Glycobiology, 17, 1061-1069 (2007).


28.   Motohiro Nonaka, Bruce Yong Ma, Misato Ohtani, Akitsugu Yamamoto, Masayuki Murata, Kiichiro Totani, Yukishige Ito, Keiko Miwa, Wataru Nogami, Nobuko Kawasaki, Toshisuke Kawasaki, Subcellular localization and physiological significance of Intracellular mannan-binding protein, The Journal of Biological Chemistry, 282, 17908-17920 (2007).


  1. 27.   Norihito Kawasaki, Ichiro Matsuo, Kiichiro Totani, Daisuke Nawa, Noriko Suzuki, Daisuke Yamaguchi, Naoki Matsumoto, Yukishige Ito, Kazuo Yamamoto, Detection of weak sugar binding activity of VIP36 using VIP36-streptavidin complex and membrane-based sugar chains, Journal of Biochemistry (Tokyo), 141, 221-229 (2007).


26.   Shinya Hagihara, Kiichiro Totani, Yukishige Ito, Exploration of oligosaccharide-protein interactions in glycoprotein quality control by synthetic approaches, The Chemical Record, 6, 290-302 (2006).


25.   戸谷希一郎, 萩原伸也, 伊藤幸成, 有機合成化学による糖タンパク質糖鎖の機能解明, 有機合成化学協会誌, 64, 492-501 (2006).


24.   Kiichiro Totani, Yoshito Ihara, Ichiro Matsuo, Yukishige Ito, Substrate specificity analysis of endoplasmic reticulum glucosidase II using synthetic high-mannose-type glycans, The Journal of Biological Chemistry, 281 (42), 31502-31508 (2006). 　

重要論文として10月20日号 表紙採択


23.   Ichiro Matsuo, Kiichiro Totani, Atsushi Tatami, Yukishige Ito, Comprehensive synthesis of ER related high-mannose-type sugar chains by convergent strategy, Tetrahedron, 62, 8262-8277 (2006).


22.   Tadashi Suzuki, Izumi, Hara, Miyako Nakano, Gang Zhao, William J. Lennarz, Hermann Schindelin, Naoyuki Taniguchi, Kiichiro Totani, Ichiro Matsuo, Yukishige Ito, Site specific labeling of cytoplasmic peptide:N-glycanase by N,N’-diacetylchitobiose-related compounds, The Journal of Biological Chemistry, 281, 22152-22160 (2006).


  1. 21.   Kiichiro Totani, Ichiro Matsuo, Yoshito Ihara, Yukishige Ito, High-mannose-type glycan modifications of dihydrofolate reductase using glycan-methotrexate conjugates, Bioorganic Medicinal Chemistry, 14 (15), 5220-5229 (2006). 


20.   Kiichiro Totani, Yoshito Ihara, Ichiro Matsuo, Hiroyuki Koshino, Yukishige Ito, Synthetic substrates for an endoplasmic reticulum protein folding sensor, UDP-glucose: glycoprotein glucosyltransferase, Angewandte Chemie International Edition, 44 (48), 7950-7954 (2005).


19.   Yukishige Ito, Shinya Hagihara, Ichiro Matsuo, Kiichiro Totani, Structural approaches to the study of oligosaccharides in glycoprotein quality control, Current Opinion in Structural Biology, 15, 481-489 (2005).


18.   Kiichiro Totani, Yukishige Ito, Synthesis and application of novel sugar chain molecular probe “Glycan-MTX”, Trends in Glycoscience and Glycotechnology, 17, 121-130 (2005).


17.   Ichiro Matsuo, Toshinori Kashiwagi, Kiichiro Totani, Yukishige Ito, First chemical synthesis of triglucosylated tetradecasaccharide (Glc3Man9GlcNAc2), a common precursor of asparagine-linked oligosaccharides, Tetrahedron Letters, 46, 4197-4200 (2005).

重要論文として6月13日号 表紙採択


16.   Sachiko Nakamura, Fumio Yagi, Kiichiro Totani, Yukishige Ito, Jun Hirabayashi, Comparative analysis of carbohydrate-binding properties of 2 tandem repeat-type Jacalin-related lectins, Castanea crenata agglutinin and Cycas revoluta leaf lectin, FEBS Journal, 272, 2784-2799 (2005).


15.   Shinya Hagihara, Kiichiro Totani, Ichiro Matsuo, Yukishige Ito, Thermodynamic analysis of interactions between N-linked sugar chains and Fbs1, Journal of Medicinal Chemistry, 48, 3126-3129 (2005).

  1. 14.   Midori A. Arai, Ichiro Matsuo, Shinya Hagihara, Kiichiro Totani, Jun-ichi Maruyama, Katsuhiko Kitamoto, Yukishige Ito, Design and synthesis of oligosaccharides that interfere with glycoprotein quality control system, ChemBioChem, 6, 2281-2289 (2005).


13.   Kiichiro Totani, Ken-ichi Takao, Kin-ichi Tadano, Sugar as a tool for asymmetric synthesis: Some novel approaches, Synlett, 2066–2080 (2004).


12.   Kiichiro Totani, Ichiro Matsuo, Maki Takatani, Midori A. Arai, Shinya Hagihara, Yukishige Ito, Synthesis of glycoprotein molecular probes for the analyses of protein quality control system, Glycoconjugate Journal, 21 (1-2), 69-74 (2004). 


  1. 11.   Kiichiro Totani, Ichiro Matsuo, Yukishige Ito, Tight binding ligand approach to oligosaccharide-grafted protein, Bioorganic Medicinal Chemistry Letters, 14 (9), 2285-2289 (2004).


10.   Shingo Asano, Tetsuo Tamai, Kiichiro Totani, Ken-ichi Takao, Kin-ichi Tadano, Highly stereoselective 1,4-addition of the enolate generated from 6-deoxy-D-glucopyranoside-derived propionyl ester to methyl crotonate: Application to total synthesis of (-)-Lasiol, Synlett, 2252-2254 (2003). 


  1. 9.    Tetsuo Tamai, Shingo Asano, Kiichiro Totani, Ken-ichi Takao, Kin-ichi Tadano, Highly stereoselective [3+2] cycloadditions of nitrile oxides to methyl 4-O-acryloyl-6-deoxy-2,3- O-(t-butyldimethylsilyl)-α-D-glucopyranoside, Synlett, 1865-1867 (2003).


8.    Takayuki Nagatsuka, Shuhei Yamaguchi, Kiichiro Totani, Ken-ichi Takao, Kin-ichi Tadano, Highly distereoselective Diels-Alder reactions of acrylic esters incorporated into a variety of hexopyranosides , Journal of Carbohydrate Chemistry, 20, 519-535 (2001).


7.    Kiichiro Totani, Shingo Asano, Ken-ichi Takao, Kin-ichi Tadano, Highly stereoselective α-alkylations, 1,4-additions, and one-pot 1,4-addition/α-methylations achieved on 4-O-acyl and 4-O-crotonyl derivatives of methyl 6-deoxy-2,3-di-O-(t-butyldimethylsilyl)-α-D-glucopyranoside, Synlett, 1772-1776 (2001).


6.    Kiichiro Totani, Takayuki Nagatsuka, Shuhei Yamaguchi, Ken-ichi Takao, Shigeru Ohba, Kin-ichi Tadano, Highly diastereoselective 1,4-addition of an organocuprate to methyl α-D-gluco-, α-D-manno-, or α-D-galactopyranosides tethering an α,β-unsaturated ester. Novel asymmetric access to β-C-substituted butanoic acids, Journal of Organic Chemistry, 66, 5965-5975 (2001).


  1. 5.   Takayuki Nagatsuka, Shuhei Yamaguchi, Kiichiro Totani, Ken-ichi Takao, Kin-ichi Tadano, Highly stereoselective Diels-Alder reactions achieved on some hexopyranosidic templates, Synlett, 481-484 (2001).


4.   Ryosuke Munakata, Kiichiro Totani, Ken-ichi Takao, Kin-ichi Tadano, Highly stereoselective Lewis acid mediated conjugate radical additions to methyl α-D-glucopyranoside derivatives tethering an unsaturated ester moiety at C-4, Synlett, 979-982 (2000).


  1. 3.   Jun Ishihara, Koji Hagihara, Hiroyuki Chiba, Kouichi Ito, Yumiko Yanagisawa, Kiichiro Totani, Kin-ichi Tadano, Synthetic studies of viridenomycin. Construction of the cyclopentene carboxylic acid part, Tetrahedron Letters, 41, 1771-1774 (2000). 


  1. 2.  Kiichiro Totani, Takayuki Nagatsuka, Ken-ichi Takao, Shigeru Ohba, Kin-ichi Tadano, Highly stereoselective 1,4-conjugate addition of organocopper reagents to methyl α-D-glucopyranoside derivatives tethering an unsaturated ester moiety at C-4 or C-6, Organic Letters, 1, 1447-1450 (1999).


1.   Takeshi Murata, Yumiko Yanagisawa, Makiko Aoyama, Hirona Tsushima, Kiichiro Totani, Shigeru Ohba, Kin-ichi Tadano, A chiral cyclohex-2-enone carrying a hexofuranosyl substituent which directs highly stereoselective 1,4-conjugate additions, Tetrahedron: Asymmetry, 9, 4203-4217 (1998).



Patent / 特　許

  1. 1. 中町優斗, 田中伸司, 戸谷希一郎,  栗原大輝　「糖ペプチドを製造する方法」特許第7261366号　出願日　2022年5月30日



Books / 著　書


6. 岩本将吾, 松尾一郎, 戸谷希一郎,  糖タンパク質品質管理の稼働状況を知る〜化学合成基質による糖鎖プロファイルの再構成〜, 糖鎖の新機能開発・応用ハンドブック; 秋吉一成 監修; NTS: 東京, 2015; pp350-355.


5.  武田陽一，戸谷希一郎，伊藤幸成， 高マンノース型糖鎖の合成とバイオロジーへの展開, 第三の生命鎖糖鎖の機能と疾患;　門松健治／遠藤玉夫／岡昌吾／北川裕之 監修; 羊土社: 東京, 2013; pp160-168.

4.  Kiichiro Totani, Kin-ichi Tadano, 1,4-Addition of nucleophiles to α,β-unsaturated carbonyl compounds, Carbohydrates-Tools for Stereoselective Synthesis; M.M.K. Boysen (Ed.); Wiley-VCH Weinheim, 2010: in press


3.  戸谷希一郎, N-結合型糖鎖プローブの合成とタンパク質品質管理機構解析への応用, 複合糖質の化学と最新応用技術;　正田晋一郎／稲津敏行 監修; シーエムシー出版: 東京, 2009; pp144-153.


2.  Kiichiro Totani, Kin-ichi Tadano, Monosaccharides as chiral auxiliaries and ligands for asymmetric synthesis, Glycoscience-Chemistry and Chemical Biology, 2nd edition; B. Fraser-Reid, K. Tatsuta, J. Thiem (Eds.); Springer- Berlin Heidelberg, 2008: pp1029-1075.　４月３０日


1.  伊藤幸成, 松尾一郎, 戸谷希一郎, 糖鎖合成化学の新展開 - 高マンノース型糖鎖の合成を例にして, 糖鎖科学の新展開; 谷口直之／伊藤幸成 監修; NTS: 東京, 2005; pp356-363.





Press Release / 記者発表

1.  独立行政法人 理化学研究所　研究成果発表　平成18年10月18日

   タンパク質品質管理を司る鍵酵素「グルコシダーゼII」の機能を解明 -化学合成を基盤とした分子レベルの手法で解明-

   WEB版: http://www.riken.jp/r-world/research/results/2006/061018/index.html




新聞掲載

1.  化学工業日報　平成18年10月25日

   「グルコシダーゼII　分子レベルで機能解明　理研-JST　神経疾患治療に寄与」


  1. 2. 日刊工業新聞　平成18年10月20日　

   「グルコシダーゼII　たんぱく質の適切な折り畳み　理研などが機能解明」





解説記事

2.  RIKEN RESEARCH, 2008, Vol. 3, Number 8 (August), pp.11

     WEB版: http://www.rikenresearch.riken.jp/research/177/

     Research Highlight “Working well in a crowded cell”


1.  RIKEN RESEARCH, 2007, Vol. 2, Number 4 (April), pp.3-4

     WEB版: http://www.rikenresearch.riken.jp/research/177/

     Highlight of the month  “One sugar or two”